The present invention provides a method for producing a SAMe-containing raw material having a high SAMe content, and a cosmetic, an external preparation, and a health food containing the SAMe-containing liquid raw material. A heating and dissolving step of adding water and brown sugar to a culture tank and heating and dissolving, a culture step of adding yeast to a culture tank and culturing, and a separation step of separating the medium and yeast by centrifugation The culture stop timing in the culturing step was determined from when the turbidity of the culture broth changed from rising to falling until the turbidity decreased by 15%. In addition, after the separation step, there is a drying step in which the yeast is freeze-dried to obtain a dry powder, or a lysis treatment step for destroying the cells of the obtained yeast, and extraction with water under acidic conditions And an extraction step for performing. [Selection] Figure 1【課題】ＳＡＭｅ含有量が高いＳＡＭｅ含有原料の製造方法、並びにＳＡＭｅ含有液体原料が配合された化粧品、外用剤及び健康食品を提供すること。【解決手段】培養タンクに水と黒糖を投入し、加温溶解する加温溶解工程と、培養タンクに酵母を投入して培養する培養工程と、遠心分離によって培地と酵母に分離する分離工程とを有し、培養工程における培養停止タイミングを、培養液の濁度が上昇から下降に転じた時から濁度が１５％低下するまでとした。また、分離工程の後に、酵母をフリーズドライ乾燥して乾燥粉末を得る乾燥工程を有するか、あるいは得られた酵母に対して菌体の破壊を行う溶菌処理工程と、酸性条件下で水による抽出を行う抽出工程とを有する。【選択図】 図１
