The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to compelement component 5 (C5).本發明係關於結合於補體因子P之抗體或其抗原結合片段及其用途,以及抗P因子抗體與結合於補體組分5(C5)之抗體或其抗原結合片段的組合。