The invention provides an antibody or antigen binding fragments thereof that binds to 3pE Aβ and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer’s disease or other β-amyloid-related diseases.本發明提供一種結合至3pE Aβ之抗體或其抗原結合片段、以及製造及使用該抗體或其抗原結合片段之方法,包括使用於配方、投予、及套組。所揭示之抗體及其抗原結合片段以及方法係有用於阿茲海默症或其他β類澱粉相關疾病之診斷、預後及治療。