LOOMIS, MARIA-CRISTINA,卢米斯 玛丽亚克里斯蒂娜,盧米斯 瑪麗亞克里斯蒂娜,F. GARCIA-MARTINEZ, LEON F.,贾西亚马帝兹 李奥,賈西亞馬帝茲 李奧,H. DUTZAR, BENJAMIN H.,杜萨 班杰明,杜薩 班傑明,S. ALLISON, DANIEL S.,艾利森 丹尼尔,艾利森 丹尼爾,L. HENDRIX, KATHERINE LEE,汉德,卢米斯 玛丽亚克里斯蒂娜,盧米斯 瑪麗亞克里斯蒂娜,贾西亚马帝兹 李奥,賈西亞馬帝茲 李奧,杜萨 班杰明,杜薩 班傑明,艾利森 丹尼尔,艾利森 丹尼爾
申请号：
TW106112586
公开号：
TW201738272A
申请日:
2017.04.14
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.本發明係有關對PACAP具有結合特異性之抗體及其抗原結合片段。該等抗體及其抗原結合片段包含本文所述之VH、VL及CDR多肽之序列，及編碼其之聚核苷酸。本文所述之抗體及抗原結合片段結合於及/或競爭結合於人類PACAP上與抗PACAP抗體相同之線性或構形抗原決定基。本發明涵蓋結合於一或多種官能或可偵測部分之抗PACAP抗體及其結合片段之結合物。亦涵蓋製備該等抗PACAP抗體及其抗原結合片段之方法。本發明之其他實施例涵蓋使用抗PACAP抗體及其結合片段來診斷、分析及治療與PACAP有關之疾病及病症及其中諸如血管擴張、畏光、肥大細胞去顆粒及/或神經元激活之PACAP相關活性的拮抗作用將在治療上有益之病狀。
