The present invention involves an anti 4-1BB antibody, antigen binding fragment and pharmaceutical use thereof. In more details, the present application refers to a chimeric antibody or humanized antibody comprising CDRs of said anti 4-1BB antibody, as well as pharmaceutical composition comprising human anti 4-1BB antibody or antigen binding fragment thereof, and also refers to its use as anti-cancer medicament. In particular, the present application refers to an humanized anti 4-1BB antibody, for use in the preparation of medicament for treatment of disease or disorder mediated by 4-1BB.本申請涉及抗4-1BB抗體、其抗原結合片段及其醫藥用途。進一步地，本申請涉及包含該抗4-1BB抗體CDR區的嵌合抗體、人源化抗體，以及包含人抗4-1BB抗體或其抗原結合片段的醫藥組成物，以及其作為抗癌藥物的用途。尤其地，本申請涉及一種人源化的抗4-1BB抗體，在製備用於治療4-1BB介導的疾病或病症的藥物中的用途。
