PROBLEM TO BE SOLVED: To provide a sustained-release solid formulation which is not affected by the environment within living body and compression molding force, and little in the variation of retention time in gastrointestinal tract, and capable of controlling the elution of active ingredients to zero order elution etc.SOLUTION: This sustained-release solid formulation is a solid formulation containing at least an active ingredient and at least an elution controlling base, and obtained by compression molding, the elution controlling base contains modified starch having a water retaining capacity of 400%, gel push-in load value of not lower than 200 g, water solubles content of 40-95 wt.%, the passing particles through 75 &mum sieve mesh of not smaller than 90 wt.%, the passing particles through 32 &mum sieve mesh of not smaller than 20 wt.%, and an average particle diameter of not smaller than 20 &mum but smaller than 50 &mum in the range of not lower than 5.0 wt.% but lower than 99.9 wt.%.COPYRIGHT: (C)2007,JPO&INPIT【課題】 生体内環境や圧縮成形力に影響を受けず、胃腸管滞留時間の変動も小さい、活性成分の溶出が0次溶出等に制御可能な徐放性固形製剤を提供する。【解決手段】 1種以上の活性成分と1種以上の溶出制御基剤とを含有し、圧縮成形により得られる固形製剤であって、前記溶出制御基剤は、保水量が400%以上であり、ゲル押込み荷重値が200g以上であり、水溶性成分量が40~95重量%であり、目開き75μmの篩いを通過する粒子が90重量%以上であり、目開き32μmの篩いを通過する粒子が20重量%以上であり、かつ平均粒径が20μm以上50μm未満の加工澱粉を5.0重量%以上99.9%重量%以下の範囲で含む、徐放性固形製剤。【選択図】 図7
