Claim 1: a compound characterized by Structural formula (1), where: L1, L2 and L3 with carbons bound to the Aromatic ring is a Ring of 12 members which contains 5 - 0 - 4 hetero n, o, S, P and / or if； L1, L2 or L3 Select regardless of A divalent Group substituents is a Link, - O -, - C (r15r16 nr3) - - - - S (o) n -, P - (o) -,If (r4r5) -, - C (o) -, - C (o) o -, and alquenilo alkoxyl, alkyl, cycloalkyl, aryl, heteroaryl cicloalcoxilo, heterocycle,,, amide, carbamate, urea and sulfonamide substituted； n is 0, 1 or 2； u or V is Regardless, CH N, CF, or ICC, CCN, W, X, and Z is Regardless, c or N； and NRN, N, or, S, or - crarb； RN is Hydrogen, c1-4 alkyl, cycloalkyl C3 - C4 - 5 6, heterocycle, aryl,Heteroaryl amide, sulfonamide, or carbamate； ra, RB is independently Hydrogen, Methyl or cycloalkyl together form a C3 - 6 - 0 OR 1 atom of porta or NR1； r1 is selected from Hydrogen Halide, - CF3, - CN, - H, - C (o) C (o) or6 -, - C (o) nhr7, - C (o) n (OH) R7, - C (= OME, nr7) - C (= nhr7 nome), (C nhr7, - ch = Noh) (Cf3) nhr8, nhr9, CH (CN) - S (o) - C (= 2nhr10, nhr11 NCN),And a group of formulas (2)； R2 is an aryl or heteroaryl substituted or non substituted； R3 is selected from the group consisting of hydrogen, alquilcarbonilo, cicloalquilcarbonilo, alcoxilcarbonilo, cicloalcoxicarbonilo, alquilsulfonilo and cicloalquilsulfonilo； R4 and R5 are independently Methyl, Ethyl, ciclopropilo； R6 is Hydrogen, c1-4 alkyl, Allyl,Ciclopropilo or benzyl； R7 is Hydrogen, alquilo u00a0 c1-4, ciclopropilo alkoxyl, c1-4, ciclopropoxi, alquilsulfonilo or cicloalquilsulfonilo； R8, R9, R10, R11 is independently Hydrogen, c1-4 alkyl, alkoxyl ciclopropilo, c1-4, or ciclopropoxi R15 and R16； is independently Hidr u00f3gen Or, hydroxyl, AZIDE, alquenilo alquinilo C2 C2 - 4 - 4, ciclopropilo c1-4 alkyl, alkoxyl, c1-4,Or ciclopropoxi R15 and R16 Are Together or a carbonyl or alquenilideno c1-4 or R15 and R16 United with the carbon to which they are linked, forming a Ring of 3 - 6 members th
