Pharmaceutical compositions comprising these compounds and the use of such compounds in the treatment of diseases, including cancer.Claim 1: a compound of formula (1) or its tautomeric forms or estereoqu u00edmicamente Isomeric N - oxides or their pharmaceutically acceptable salts, solvates, where the ring and aromatic or Heterocyclic carboc u00edclico represents a group of 6 members； G and J are ma Nera is independent of c or N； Q is CR4 or N； r1 is selected from c1-4 alkyl,Alquenilo cycloalkyl C3 and C2 - 4 - 8 - (CH2) s, where such alquenilo c1-4 alkyl, cycloalkyl C3 and C2 - 4 - 8 can be replaced optionally by one or More groups ra ra is selected from Halogen, alkyl - and - or - C1 - 2A and R2B is 6； independently selected from Hydrogen, alkyl C1 - 6 Alquenilo alquinilo C2 C2 - 6, - 6, - C (= o) NH (2) - Q (alkyl) - 6 (C1)- (CH2) S - (heterociclilo 3 - 12 members), and - S - (CH2) carbociclilo C3 - 12 or R2B groups 2A and, together with the carbon Atom to which they are attached, can be joined to form a Group carbociclilo or heterociclilo saturated 3 - 10 members, where the alkyl alquenilo C1 - C2 - 6, 6, alqui Nile C2 - 6Heterociclilo groups and carbociclilo may be optionally substituted by one or More groups RB r3b R3A and selected independently Hydrogen, alkyl alquenilo C1 - C2 - 6, 6, 6 alquinilo C2 -, - C (= o) NH (2) - Q (C1 alkyl) - 6 - (Q,) S - (CH2) heterociclilo 3 - 12 members) - (CH2) S - ca Rbociclilo C3 - 12, - C (= o) - (heterociclilo 3 - 12 members), and - C (= o) - carbociclilo C3 - 12Groups or R3A and R2H, together with the carbon Atom to which they are attached, can be joined to form a Group carbociclilo or heterociclilo saturated 3 - 10 members, where the alkyl groups alquenilo C1 - C2 - 6, 6, 6 heterociclilo alquinilo C2, and carbociclilo can be optionally Replaced by one or More groups RB； R4 is selected from Hydrogen, alkyl alquenilo C1 - C2 - 6 6Alquinilo C2 - 6, - C (= o) NH (2) - Q (C1 alkyl) - 6 - (CH2) Q (S) - 3 - heterociclilo 12 memb
