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FUSED BICYCLIC COMPOUND
专利权人:
Yoichi TAKAHASHI
发明人:
Yoichi TAKAHASHI,Nobumasa Awai,Hidenori Akatsuka,Takayuki Kawaguchi,Toru Iljima
申请号:
US13561662
公开号:
US20130029979A1
申请日:
2012.07.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]:wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.
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