抗-α4β7抗體之調配物农业专利-农业专业知识服务系统

发明人:: FOX, IRVING H,福克斯　艾文Ｈ,SCHOLZ, CATHERINE,史可兹　凯萨琳,史可茲　凱薩琳,VARGA, CSANAD M.,瓦加　科沙纳德Ｍ,瓦加　科沙納德Ｍ,PALANIAPPAN, VAITHIANATHAN,派伦尼亚潘恩　维斯亚纳桑,派倫尼亞潘恩　維斯亞納桑,BROWN, JASON,布朗　杰森,布朗　傑森,DILUZIO, WILLOW,迪鲁兹欧　威洛,福克斯艾文H,史可兹凯萨琳,史可茲凱薩琳,瓦加科沙纳德M,瓦加科沙納德M,派伦尼亚潘恩维斯亚纳桑,派倫尼亞潘恩維斯亞納桑,布朗杰森,布朗傑森,迪鲁兹欧威洛

摘要：: Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.本發明描述包含非還原糖、抗-α4β7抗體及至少一種胺基酸之混合物的抗體調配物。所揭示之調配物具有改良之穩定性、減少之聚集體形成，且可延遲其中抗-α4β7抗體之降解，或呈現其任何組合。本發明進一步提供一種此等抗體調配物之安全給藥方案，其易於遵循，且在活體內產生治療有效量之抗-α4β7抗體。