抗－α４β７抗體之調配物农业专利-农业专业知识服务系统

发明人:: FOX, IRVING H,福克斯　艾文Ｈ,SCHOLZ, CATHERINE,史可兹　凯萨琳,史可茲　凱薩琳,ROSARIO, MARIA,罗莎莉欧　玛利亚,羅莎莉歐　瑪利亞,JENKINS, HELEN,珍琴丝　海伦,珍琴絲　海倫,VARGA, CSANAD M.,瓦加　科沙纳德Ｍ,瓦加　科沙納德Ｍ,PALANIAPPAN, VAITHIANATHAN,派伦尼亚潘恩　维斯亚纳桑,福克斯艾文H,史可兹凯萨琳,史可茲凱薩琳,罗莎莉欧玛利亚,羅莎莉歐瑪利亞,珍琴丝海伦,珍琴絲海倫,瓦加科沙纳德M,瓦加科沙納德M,派伦尼亚潘恩维斯亚纳桑

摘要：: Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.本發明描述包含抗-α4β7抗體、抗氧化劑或螯合劑及至少一種游離胺基酸之混合物的抗體調配物。所揭示之調配物可具有改良之穩定性、減少之聚集體形成或其兩者。本發明進一步提供一種此等抗體調配物之安全給藥方案，其易於遵循，且在活體內產生治療有效量之該抗-α4β7抗體。