抗-α4β7抗體之調配物农业专利-农业学术服务平台

发明人:: FOX,IRVING H,福克斯艾文　H,SCHOLZ,CATHERINE,史可兹凯萨琳,史可茲凱薩琳,ROSARIO,MARIA,罗莎莉欧玛利亚,羅莎莉歐瑪利亞,JENKINS,ERICA HELEN,珍琴丝艾瑞卡　海伦,珍琴絲艾瑞卡　海倫,VARGA,CSANAD M.,瓦加科沙纳德　M,瓦加科沙納德　M,PALANIAPPAN,VAITHIANATHAN,派伦尼亚潘恩维斯亚纳,福克斯艾文 H,珍琴丝艾瑞卡海伦,珍琴絲艾瑞卡海倫,瓦加科沙纳德 M,瓦加科沙納德 M

摘要：: Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.本發明描述包含抗-α4β7抗體、抗氧化劑或螯合劑及至少一種游離胺基酸之混合物的抗體調配物。所揭示之調配物可具有改良之穩定性、減少之聚集體形成或其兩者。本發明進一步提供一種此等抗體調配物之安全給藥方案，其易於遵循，且在活體內產生治療有效量之該抗-α4β7抗體。