The present invention provides for compositions of anti-M-CSF antibodies comprising a chelating agent and/or histidine. Also provided are methods of treating M-CSF-mediated disorders with pharmaceutical formulations of anti-M-CSF antibodies, including inflammatory diseases and neoplasia disorders.本發明提供包含螯合劑之抗-CTLA-4抗體之新穎組合物,本發明亦提供用CTLA-4抗體之新穎組合物治療包括各種贅瘤病症之疾病及病症的方法。