Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer’s disease, Progressive Supranuclear Palsy and Pick’s disease.本發明係關於針對人類tau聚集體之單株抗體、包含此等tau抗體之組合物,及使用此等tau抗體治療神經退化疾病(包括阿茲海默氏病(Alzheimer’s disease)、進行性核上性麻痺及匹克氏病(Pick’s disease))之方法。