Therapeutic polypeptides, homologues thereof, fragments thereof, and use in modulating platelet-mediated aggregation

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专利权人:

アブリンクス;エン．ヴェー．;アブリンクス エン.ヴェー.

发明人:

シレンス，カレン,シレンス,カレン

申请号：

JP2010164586

公开号：

JP5491308B2

申请日:

2010.07.22

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a polypeptide used for treating the state of requiring the modulation of platelet-mediated aggregation.SOLUTION: This therapeutic polypeptide consists of a polypeptide comprising at least one single domain antibody directed to vWF, vWF A1 domain, activated vWF A1 domain, vWF A3 domain, gpIb and/or collagen, the homologues of the polypeptide and/or the functional part of the polypeptide. A method for producing the polypeptide, a method for coating devices used in medical treatments (e.g. PCTA, stenting) with the polypeptide, a method and kit for screening agents modulating the platelet-mediated aggregation, and a kit for the diagnosis of the diseases related to the platelet-mediated aggregation are also provided.

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中国工程科技知识中心

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