Provided herein are methods of treating, preventing, ameliorating or managing mucopolysaccharidosis (nmMPS) disease, comprising administering a 1,2,4-oxadiazole benzoic acid to a patient having a nmMPS. In particular, provided herein are methods of treating, preventing, ameliorating or managing a MPS.本發明提供治療、預防、改善或管理黏多糖病(nmMPS)疾病之方法,其包含向患有nmMPS之患者投與1,2,4-二唑苯甲酸。特別地,本發明提供治療、預防、改善或管理MPS之方法。