This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against intracellular components that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.本發明提供一種不使用外源性靶向序列或化學組合物而治療病症或疾病之組合物及方法。本發明係有關針對細胞內造成病症或疾病的成分之單域抗體(sdAbs)、蛋白質及包括該單域抗體之多肽。本發明亦包含編碼該單域抗體、蛋白質及多肽之核酸，以及包括該單域抗體之組合物。本發明包含該等核酸、單域抗體及編碼該單域抗體之核酸在預防性、治療性或診斷性目的上之用途。
