Compound conforming to the general formula (I): in which m represents 0, 1, 2 or 3； n represents 0, 1, 2 or 3； X represents an oxygen or sulphur atom or an SO or SO2 group； R1 and R2 represent independently of one another a hydrogen atom or a C1-3 alkyl group, or R1 and R2 together form a group -(CH2)p-, where p represents an integer ranging from 1 to 5 such that n + p is an integer ranging from 2 to 5； R3 represents a hydrogen or fluorine atom or a hydroxyl or methyl group； R4 represents a group of general formula CHR5CONHR6 in which R5 represents a hydrogen atom or a C1-6 alkyl group and R6 represents a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkylene group； Y represents a group selected from in particular a phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, thiazolyl, naphthyl, quinolinyl, isoquinolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, cinnolinyl, benzofuranyl, dihydrobenzofuranyl, benzothienyl, dihydrobenzothienyl, indolyl, isoindolyl, indolinyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzoxadiazolyl and benzothiadiazolyl, this group being optionally substituted； in the form of a base, addition salt of an acid, hydrate or solvate. Application in therapy.本發明係關於呈鹼、酸加成鹽、水合物或溶劑合物形式、符合通式(I)之化合物：其中m代表0、1、2或3；n代表0、1、2或3；X代表氧原子或硫原子或SO或SO2基團；R1及R2彼此獨立地代表氫原子或C1-3烷基，或R1及R2一起形成基團-(CH2)p-，其中p代表在1至5範圍內之整數以使得n+p為2至5範圍內之整數；R3代表氫原子或氟原子或羥基或甲基；R4代表通式CHR5CONHR6基團，其中R5代表氫原子或C1-6烷基且R6代表氫原子或C1-6烷基、C3-7環烷基或C3-7環烷基-C1-6伸烷基；Y代表尤其選自下列基團之基團：苯基、吡啶基、嗒嗪基、嘧啶基、吡嗪基、三嗪基、噻唑基、萘基、喹啉基、異喹啉基、酞嗪基、喹唑啉基、喹喏啉基、啶基、喏啉基、苯幷呋喃基、二氫苯幷呋喃基、苯幷噻吩基、二氫苯幷噻吩基、吲哚基、異吲哚基、吲哚啉基、苯幷咪唑基、苯幷噁唑基、苯幷異噁唑基、苯幷噻唑基、苯幷異噻唑基、苯幷三唑基、苯幷噁二唑基及苯幷噻二唑基，此基團視情況經取代。本發明亦係關於其於治療上之應用。
