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2. Bifunctional molecules with antibody recruitment activity and initial inhibition activity of human immunodeficiency virus
专利权人:
YALE UNIVERSITY
发明人:
SPIEGEL, DAVID,PARKER, CHRISTOPHER
申请号:
PE2013001206
公开号:
PE20140406A1
申请日:
2011.11.17
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
It's an abiotic formula compound,Among them, ABT is an end that binds to the antibody, including a haptone; linker is a binding molecule that chemically binds abt with y or directly with INOL; aryl is an aromatic or heteroaromatic group; ery is O, NHC (o) NH, s (o) 2O, among others; x2 es h, (CH2) Noh, (CH2) NCOH, entre Others: X3 is h, (CH2) Noh, (CH2) NCOH, among others; R1 is h or C1-C3 tar; I is 0 or 1; K is 0, 1, 2 or 3; n is 0 or 1 to 6 integers; Y3 is h or C1-C3 tar; RN is h or C1-C3 optional tar, replaced by or halogenated. A pharmaceutical composer was also mentioned These compounds are inhibitors of HIVREFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (A), DONDE ABT ES UN EXTREMO DE UNION A ANTICUERPO QUE COMPRENDE UN HAPTENO; LINKER ES UNA MOLECULA ENLAZADORA LA CUAL ENLAZA QUIMICAMENTE ABT A RY O DIRECTAMNETE AL GRUPO INDOL EN EL ATOMO DE CARBONO AL CUAL RY SE ENCUENTRA UNIDO; ARYL ES UN GRUPO AROMATICO O HETEROAROMATICO; RY ES O, NHC(O)NH, S(O)2O, ENTRE OTROS; X2 ES H, (CH2)nOH, (CH2)nCOOH, ENTRE OTROS; X3 ES H, (CH2)nOH, (CH2)nCOOH, ENTRE OTROS; R1 ES H O ALQUILO C1-C3; i ES 0 O 1; k ES 0, 1, 2 O 3; n ES 0 O UN ENTERO DE 1 A 6; Y3 ES H O ALQUILO C1-C3; RN ES H O ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON O O HALOGENO. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL VIH
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