AMBERG, WILHELM,OCHSE, MICHAEL,LANGE, UDO,KLING, ANDREAS,BEHL, BERTHOLD,HORNBERGER, WILFRIED,MEZLER, MARIO,HUTCHINS, CHARLES
申请号：
PE2011001496
公开号：
PE20120062A1
申请日:
2010.02.16
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to a monomer amine derivative composed of a 5 or 6 member ring a； R is r1-w-a1-q-y-a2-x1 -.Where R1 is h, tar (C1-C6),Hydroxy group (C1-C4),Carbamate (C1-C4),Among other things, W is nr8 or alliance, where R8 is h or tar (C1-C6)；A1 is asphalt (C1-C4) or alliance； q is s (o) 2 or C (o)；It is nr9 or alliance, where R9 is h, tar (C1-C6),Cyclopropyl (c3-c12),A2 is mainly asphalt (C1-C4),Alquenileno（C2-C4），X1 is O, s, tar (C1-C4), among other things,Among other things, R2 is h, halogen, tar (C1-C6),Among others, R3 is h, halogen, oxygen (C1-C6),Among other things, R4A is h, ch2cn, CHO, etc.； r4b is h, asphalt (C1-C6),Amino, among other things； X2 is an alliance, or s, etc.； X3 is an alliance, or s, etc.； R5 is arilo (C6-C12),Cyclopropyl (c3-c12),Among other things, n is 0 to 2. The most popular compounds are: n - (2 - (7-amino-8 - (3,4-dichlorobenzene) - 5,6,7,8-tetrahydrobenzofuran-2-iloxi) ethyl) - 1-methyl-1h-imidazole-4-sulfosamide； {2 - [7-amino-8 - (3,4-dichlorobenzene) - 5,6,7,8-tetrahydro-naftelen-2-ilxi] - ethyl} - imino-formic acid 1-pyridyl group. He also mentioned a pharmaceutical composer These compounds are inhibitors of glycerol GlyT1 vector, which are useful in the treatment of schizophrenia, dementia and anxiety.SE REFIERE A COMPUESTOS DERIVADOS DE AMINOTETRALINA DE FORMULA (I) DONDE A ES UN ANILLO DE 5 O 6 MIEMBROS； R ES R1-W-A1-Q-Y-A2-X1-, EN DONDE R1 ES H, ALQUILO(C1-C6), HIDROXIALQUILO(C1-C4), AMINOALQUILO(C1-C4), ENTRE OTROS； W ES NR8 O UNA UNION, DONDE R8 ES H O ALQUILO(C1-C6)； A1 ES ALQUILENO(C1-C4) O UNA UNION； Q ES S(O)2 O C(O)； Y ES NR9 O UNA UNION, DONDE R9 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C12), ENTRE OTROS； A2 ES ALQUILENO(C1-C4), ALQUENILENO(C2-C4), ENTRE OTROS； X1 ES O, S, ALQUILENO(C1-C4), ENTRE OTROS； R2 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS； R3 ES H, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS； R4a ES H, CH2CN, CHO, ENTRE OTROS； R4b ES H, ALQUILO(C1-C6), AMINO, ENTRE OTROS； X2 ES UNA UNION, O, S, ENTRE OTROS； X3 ES UNA UN
