BLOMGREN, Peter A.,CURRIE, Kevin S.,GEGE, Christian,KROPF, Jeffrey E.,XU, Jianjun
申请号：
PE2018003208
公开号：
PE20190329A1
申请日:
2017.06.09
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
A compound according to formula (I),Q is phenyl or pyridylene, which is replaced by one or two substitutes between hydrogen halide, methyl, alcoy-c1-4 and other substances； n or CH； a is pyridine or phenyl, which is replaced by one or two groups selected from hydrogen halide, alcox-c1-4, hydrocarbon-c1-4 and halogen asphalt-c1-4； Z is isoxazol, which is replaced by R1 or pyrazole； R1 is replaced by R1； R1 is the tar of C1-4 or cyclododecylquinoline-c3-6； R2 and R3 are independently selected from h, halogen, methoxy, CF3, chf2 and other substances； R4 is - co2r5 or - C (or) nr5r6； R5 is h, tar-c1-6 or mero-quilo-c1-6； R6 is h or tar-c1-6； an acceptable pharmacological salt, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body, a foreign body and a foreign body,Or their Taurus These compounds are combined with the NR1 H4 receiver, which is the fxragent. It also deals with the conditions for the use of compounds in the preparation of drugs for the treatment of diseases and / or the treatment of these nuclear receptors through combinations of these compounds, as well as the procedures for the synthesis of these compounds.Referido a un compuesto de acuerdo con la formula (I), donde Q es fenileno o piridileno, los cuales estan sustituidos con uno o dos sustituyentes entre halogeno, metilo, alcoxi-C1-4； entre otros； Y es N o CH； A es piridileno o fenileno, los cuales esta sustituido con uno o dos grupos seleccionados entre halogeno, alcoxi-C1-4, alquilo-C1-4 y halo-alquilo-C1-4； Z es isoxazol sustituido con R1 o pirazol sustituido con R1； R1 es alquilo-C1-4 o cicloalquilo-C3-6； R2 y R3 se seleccionan independientemente entre h, halogeno, metoxi, -CF3, -CHF2, entre otros； R4 es -CO2R5 o -C(O)NR5R6； R5 es H, alquio-C1-6, o halo-alquilo-C1-6； y R6 es H o alquilo-C1-6； una sal farmaceutica aceptable, un estereoisomero, una me
