SITEONE THERAPEUTICS, INC.;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
PAJOUHESH, HASSAN,MILJANICH, GEORGE,MULCAHY, JOHN,DU BOIS, JUSTIN,AXTMAN, MATTHEW,WALKER, JAMES,MERIT, JEFFREY E.
申请号：
CA2944549
公开号：
CA2944549A1
申请日:
2015.04.09
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10',11'-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10',11'-modified saxitoxins are of Formula I: where R1, R2 and R3 are as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10',11' modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human.
