Siteone Therapeutics, Inc.;The Board of Trustees of the Leland Stanford Junior University
发明人:
Pajouhesh, Hassan,Miljanich, George,Mulcahy, John,Du Bois, Justin,Axtman, Matthew,Walker, James,Merit, Jeffrey E.
申请号：
AU2015243437
公开号：
AU2015243437B2
申请日:
2015.04.09
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10',11'-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10',11'-modified saxitoxins are of Formula I: where R
