John P. LEVY,Rebecca A. REED,Joseph MCNULTY,Robert G. JOHNSON, JR.
申请号：
US14214522
公开号：
US20140288163A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
