John P. LEVY,Rebecca A. REED,Joseph McNULTY,Robert G. JOHNSON, Jr.
申请号：
US15892295
公开号：
US20180236101A1
申请日:
2018.02.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
