The U.S.A.; as represented by the Secretary; Department of Health and Human Services
发明人:
Barney Graham,Wing-Pui Kong,Kayvon Modjarrad,Lingshu Wang,Wei Shi,Michael Gordon Joyce,Masaru Kanekiyo,John Mascola
申请号：
US16403211
公开号：
US20190256579A1
申请日:
2019.05.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the immune response is a protective immune response that inhibits or prevents MERS-CoV infection in the subject. Recombinant MERS-CoV polypeptides and nucleic acid molecules encoding same are also provided. Additionally, neutralizing antibodies that specifically bind to MERS-CoV S protein and antigen binding fragments thereof are disclosed. The antibodies and antigen binding fragments are useful, for example, in methods of detecting MERS-CoV S protein in a sample or in a subject, as well as methods of preventing and treating a MERS-CoV infection in a subject.
