YOON Sang Phil,KO Ki Seong,YU Ha Na,BAIK Hye Jung,YANG Won Kyu,KO Jin Young,PARK So Hyun,JUNG Sung Bum,AN Sung Won,KI Min Hyo,JUNG Sun
申请号：
SI201331022
公开号：
SI2938332T1
申请日:
2013.12.27
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more &mdash；OH (hydroxyl) groups； b) at least one phospholipid； c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety； and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.
