ROSENDAHL MARY S,MANTRIPRAGADA SANKARAM B,GOMEZ ELIANA B
申请号：
IN201717022574
公开号：
IN201717022574A
申请日:
2017.06.28
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Examples may include a method of making a protein PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein PEG conjugate. The method may further include protonating an amino group on the protein PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity PEG conjugate salt.
