PROBLEM TO BE SOLVED: To provide an anti-inflammatory analgesic agent for external use which contains a nonsteroidal anti-inflammatory analgesic component and an acidic mucopolysaccharide and is improved in transdermal absorption property.SOLUTION: The nonsteroidal anti-inflammatory analgesic agent for external use is prepared by compounding N-methylpyrrolidone in an anti-inflammatory analgesic agent for external use containing the nonsteroidal anti-inflammatory analgesic component and the acidic mucopolysaccharide. A preferable nonsteroidal anti-inflammatory analgesic component is indomethacin. A preferable acidic mucopolysaccharide is a heparinoid. The anti-inflammatory analgesic external use agent maintains high transdermal absorption property of the nonsteroidal anti-inflammatory analgesic component even if the acidic mucopolysaccharide is compounded, and exhibits excellent anti-inflammatory analgesic effect. The anti-inflammatory analgesic external use agent also has skin stimulus reducing effect based on the acidic mucopolysaccharide, and exhibits excellent effect in both of drug efficacy and sense of use.COPYRIGHT: (C)2012,JPO&INPIT【課題】非ステロイド性消炎鎮痛成分及び酸性ムコ多糖を含有する外用剤の経皮吸収性を改善した消炎鎮痛外用剤の提供。【解決手段】非ステロイド性消炎鎮痛成分、酸性ムコ多糖を含有する消炎鎮痛外用剤に、N-メチルピロリドンを含有させた消炎鎮痛外用剤。該非ステロイド性消炎鎮痛成分としては、インドメタシンであることが好ましい。該酸性ムコ多糖としては、ヘパリン類似物質であることが好ましい。該消炎鎮痛外用剤は、酸性ムコ多糖を配合しても非ステロイド性消炎鎮痛成分の経皮吸収性が高く、優れた消炎鎮痛効果を示し、さらに酸性ムコ多糖による皮膚刺激の低減効果を併せ持ち、薬効及び使用感の両方に優れた効果を有する。【選択図】なし
