The purpose of the present invention is to provide a preparation technique for improving the anti-inflammatory analgesic effect of a pharmaceutical composition for external use that includes diclofenac and/or its salt. In the pharmaceutical composition for external use, if diclofenac and/or its salt and capsaicinoid, tocopherol and/or its derivative, and ester derivative of nicotinic acid are combined together for use, and the pH value is set to be 6.1 or higher, the anti-inflammatory effect can be significantly improved, so that it dramatically improves the anti-inflammatory analgesic effect.本發明之目的在於提供一種提高包含雙氯芬酸及/或其鹽之外用醫藥組合物之消炎鎮痛作用之製劑技術。於外用醫藥組合物中,若將雙氯芬酸及/或其鹽與類辣椒素、生育酚及/或其衍生物及菸鹼酸之酯衍生物一起併用,且將pH值設定為6.1以上,則消炎作用顯著提高,從而使消炎鎮痛作用得到飛躍性提高。
