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Compuestos de tubulisina, métodos para su fabricación y su uso
专利权人:
Bristol-Myers Squibb Company
发明人:
CHENG, Heng,CONG, Qiang,GANGWAR, Sanjeev
申请号:
ES14706743
公开号:
ES2628156T3
申请日:
2014.02.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound having a structure represented by formula (I) ** Formula ** wherein R1 is H, C1-C10 substituted or unsubstituted C2-C10 substituted or unsubstituted C2-C10 substituted or substituted aryl, substituted or unsubstituted, substituted or unsubstituted heteroaryl, (CH2) 1-2O (C1-C10) substituted or unsubstituted, (CH2) 1-2O (C2-C10) substituted or unsubstituted, (CH2 ) 1-2O (C2- C10 alkynyl) substituted or unsubstituted, (CH2) 1-2OC (> = O) (C1-C10), (CH2) 1-2OC (> = O) (C2-C10) substituted or unsubstituted, (CH2) 1-2OC (> = O) (C2-C10) substituted or unsubstituted, C (> = O) (C1-C10) substituted or unsubstituted, C (> = O) (C2-C10) substituted or unsubstituted, C (> = O) (C2-C10) substituted or unsubstituted, substituted cycloaliphatic or unsubstituted, substituted heterocycloaliphatic or unsubstituted, substituted aryl or unsubstituted or substituted alkylaryl or substituted R2 is H, C1-C10 alkyl substituted or unsubstituted C2-C10 substituted or unsubstituted C2-C10 substituted or unsubstituted aryl, substituted or unsubstituted, substituted or unsubstituted heteroaryl, (CH2) 1-2O ( C1-C10) substituted or unsubstituted, (CH2) 1-2O (C2-C10) substituted or unsubstituted, (CH2) 1-2O (C2- C10 alkynyl) substituted or unsubstituted, (CH2) 1-2OC (> = O) (C1-C10), (CH2) 1-2OC (> = O) (C2-C10) substituted or unsubstituted, (CH2) 1-2OC (> = O) (C2-C10 ) substituted or unsubstituted, C (> = O) (C1-C10) substituted or unsubstituted, C (> = O) (C2-C10) substituted or unsubstituted, C (> = O) (C2- alkynyl C10) substituted or unsubstituted, substituted or unsubstituted cycloaliphatic, heterocycloaliphatic substituted or unsubstituted arylalkyl or substituted or unsubstituted alkyl substituted or unsubstituted, or ** ** Formula wherein each R2a is independently H, NH2, NHMe, Cl, F, me, Et or CN R3a and R3b are independently H, C1-C5, CH2 (C5-C6), CH2C6H5, CH2CH2OH or C6H5 R4 is Formula ** ** ** or ** Formula wherein R4a is H or C1-C3 alkyl and Y is H, OH, Cl, F, CN, Me, Et
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