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Use of idol derivatives for cancer treatment
专利权人:
COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;Centre National de la Recherche Scientifique (C.N.R.S.)
发明人:
GUILLOU, Catherine,KOZIELSKI, Frank,LABRIERE, Christophe,GUERITTE, Françoise,TCHERNIUK, Sergey,SKOUFIAS, Dimitrios,THAL, Claude,HUSSON, Henri-Philippe
申请号:
ES10730561
公开号:
ES2641182T3
申请日:
2010.06.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Use of a compound of formula (I): ** Formula ** where: - the dashed line --- represents a saturated or unsaturated bond; - Z represents a CH unit; - Y represents a unit C (R5) x - R5 represents a hydrogen atom, a (C1-C5) alkyl group, a nitrile, a carboxamide or Ar, being x 1 or 2; - R6 represents a hydrogen atom, a (C1-C5) alkyl or an Ar group; - R4, different from R5, represents a hydrogen atom, a nitrile group, an ethyne, a (C1-C5) alkyl or a carboxamide; provided that: or when R4 represents a hydrogen atom, then R5 represents a nitrile group and R6 represents an Ar group, and when R4 is different from a hydrogen atom, then one from R5 and R6, different from each other , is an Ar group; - R7 represents a hydrogen atom or a (C1-C5) alkyl group; - R1, R2 and R3, independently of each other, represent a hydrogen atom, a halogen, a hydroxyl, an amine or a (C1-C10) alkoxy radical, phenyl, benzyloxy, acetate, methylcarbamate, (C1-) alkoxy C10) acetate, said radical being optionally substituted by at least one halogen or a (C1-C10) alkoxy group; - R2 and R3 can form a condensed heterocycle with the phenyl cycle, such as a benzoxazole, optionally substituted by a (C1-C5) alkyl group; - Ar represents an aromatic radical selected from: ** Formula ** representing R 'a hydrogen atom, a halogen, a cyano group, a (C1-C5) alkyl or a (C1-C10) alkoxy, R' 'and R '' '', independently of each other, represents a hydrogen atom, a halogen or a (C1-C5) alkyl group, and R '' 'represents a hydrogen atom or a (C1-C10) alkoxy group; * * Formula ** provided that when Ar is (B), R4 represents a nitrile group and R1, R3, R5 and R7 represent a hydrogen atom and: or if the broken line is an unsaturated bond, then R2 is different from a benzyloxy group, or if the dashed line is a saturated bond, then R2 is different from a hydrogen atom; ** Formula ** with: - Ra and Rc, independently of each other, represent a hydrogen atom, a halogen , a nitro group, an amine, an amide or a (C1-C5) alkoxy; - Rb
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