Disclosed are 2,4-diamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine derivatives and analogues of the general formula (I), or a pharmaceutically acceptable salt, tautomer, solvate or polymorph thereof, wherein: A is selected from the group consisting of CH2, NCOR2, CHR3 and CR3R3； B is selected from the group consisting of CH2, NCOR4, CHR3 and CR3R3； with the proviso that when A is NCOR2 then B is not NCOR4 and with the proviso that A and B are not both selected from CH2, CHR3 or CR3R3； X is selected from CH2 or CHR5； R1 is selected from alkyl optionally substituted with one or more of the following: alkyl, cycloalkyl, hydroxyl, hydroxyalkyl, amino, nitrile, alkoxy, alkoxy-alkyl, carboxylic acid, carboxylic ester or carbamate； R2 is selected from substituted and unsubstituted alkyl, cycloalkyl, heterocycle, aryl, heteroaryl, alkylheteroaryl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, alkyl, dialkylamino, alkylamino, alkyl, alkoxy, cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, alkylaryl, heteroaryl, alkylheteroaryl or nitrile； R3 is selected from hydrogen, substituted and unsubstituted alkyl, alkoxy, alkoxy-alkyl, cycloalkyl, heterocycle, bicyclic heterocycle, alkylaryl, heteroaryl, alkylheteroaryl each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, alkyl, dialkylamino, alkylamino, alkyl, alkoxy, cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, alkylaryl, heteroaryl, alkylheteroaryl or nitrile； R4 is selected from substituted or unsubstituted alkyl, alkoxy, alkoxy-alkyl, aryl or cycloalkyl each of which is optionally substituted by heterocycle, nitrile, alkylheteroaryl or heteroaryl； and wherein R5 is selected from bicyclic heterocycle, aryl, heteroaryl, each of which is optionally substituted by one or more substi
