MC GOWAN, David Craig,PIETERS, Serge Maria Aloysius,LAST, Stefaan Julien,EMBRECHTS, Werner,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard
申请号：
ES14738751
公开号：
ES2645950T3
申请日:
2014.06.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** and one of its pharmaceutically acceptable salts, solvates or polymorphs, wherein R 1 is H, fluorine or methyl； R2 is H, halogen or C1-3 alkyl； R3 is C1-6 alkyl optionally substituted with one or more substituents independently selected from aryloxy, heterocycle, halogen, aryl, alkylamino, dialkylamino, C1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, nitrile or C1-6 alkoxy； or wherein R3 is an alkylaryl optionally substituted with one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile or C1-6 alkoxy； R4 is C1-6 alkyl optionally substituted with one or more substituents independently selected from hydroxyl, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or aryl optionally further substituted with C1-6 alkyl, and C3-7 cycloalkyl optionally substituted also with C1-6 alkyl； or where R4 is an alkylaryl optionally substituted with one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile or C1-6 alkoxy.Un compuesto de fórmula (I)**Fórmula** y una de sus sales, solvatos o polimorfos farmacéuticamente aceptables, donde R1 es H, flúor o metilo； R2 es H, halógeno o alquilo C1-3； R3 es alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre ariloxi, heterociclo, halógeno, arilo, alquilamino, dialquilamino, alquilo C1-6, ácido carboxílico, éster carboxílico, amida carboxílica, nitrilo o alcoxi C1-6； o donde R3 es un alquilarilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halógeno, ariloxi, arilo, alquilamino, dialquilamino, alquilo C1-6, ácido carboxílico, éster carboxílico, amida carboxílica, sulfonamida, nitrilo o alcoxi C1-6； R4 es alquilo C1-6 opcionalmente sustituid
