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Phthalazine derivatives.
专利权人:
Merck Patent GmbH
发明人:
BUCHSTALLER, Hans-Peter,DORSCH, Dieter,ESDAR, Chirstina,LEUTHNER, Birgitta
申请号:
ES14728832
公开号:
ES2623704T3
申请日:
2014.05.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of formula I ** Formula ** in which R1 indicates H, Hal, CH3, OCH3 or CH2OH, X indicates Ar or Cyc, Ar indicates phenyl, biphenyl or naphthyl, each being unsubstituted or mono, di or trisubstituted by HaI, NO2, CN, A, [C (R2) 2] pOR2, S (O) mR2, [C (R2) 2] pN (R2) 2, [C (R2) 2] pCOOR2, [C ( R2) 2] pCON (R2) 2, [C (R2) 2] pSO2N (R2) 2, NR2COR2, NR 2SO2R2 NR2CON (R2) 2, NHCOOA, O [C (R2) 2] nN (R2) 2, CHO and / or COA, R2 indicates H or A, A indicates unbranched or branched alkyl with 1-10 C atoms, in which two adjacent carbon atoms can form a double bond and / or one or two CH groups can be replaced and / or CH2 not adjacent by atoms of N, O and / or S and in which 1-7 atoms of H can be replaced by F, Cl and / or OH, Cyc indicates cycloalkyl with 3, 4, 5, 6 or 7 atoms of C, Hal indicates F, Cl, Br or I, m indicates 0, 1 or 2, n indicates 1, 2 or 3, p indicates 0, 1, 2, 3 or 4, and pharmaceutically acceptable salts, tautomers and stereoisomers of the same, including mixtures thereof in any proportion .Compuestos de fórmula I**Fórmula** en la que R1 indica H, Hal, CH3, OCH3 o CH2OH, X indica Ar o Cyc, Ar indica fenilo, bifenilo o naftilo, estando cada uno de ellos sin sustituir o mono, di o trisustituido por HaI, NO2, CN, A, [C(R2)2]pOR2, S(O)mR2, [C(R2)2]pN(R2)2, [C(R2)2]pCOOR2, [C(R2)2]pCON(R2)2, [C(R2)2]pSO2N(R2)2, NR2COR2, NR 2SO2R2 NR2CON(R2)2, NHCOOA, O[C(R2)2]nN(R2)2, CHO y/o COA, R2 indica H o A, A indica alquilo no ramificado o ramificado con 1-10 átomos de C, en el que dos átomos de carbono adyacentes pueden formar un doble enlace y/o pueden reemplazarse uno o dos grupos CH y/o CH2 no adyacentes por átomos de N, O y/o S y en el que pueden reemplazarse 1-7 átomos de H por F, Cl y/u OH, Cyc indica cicloalquilo con 3, 4, 5, 6 o 7 átomos de C, Hal indica F, Cl, Br o I, m indica 0, 1 o 2, n indica 1, 2 o 3, p indica 0, 1, 2, 3 o 4, y sales, tautómeros y estereoisómeros farmacéuticamente aceptables de los mismos, incluyendo mezclas de los mismos en cualqu
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