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Functional heterocytic derivatives of oxidiazol
专利权人:
MERCK SERONO S.A.
发明人:
MUZERELLE, MATHILDE,QUATTROPANI, ANNA,MONTAGNE, CYRIL,DORBAIS, JÉRÔME
申请号:
ES09768100
公开号:
ES2543205T3
申请日:
2009.12.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of formula (I): ** Formula ** where the group ** Formula ** indicates one of the following groups: ** Formula ** X indicates -CH- or -N-, Y indicates Het or Ar; Ra is A, Hal, CF3, OR3, OCF3, (CH2) nOH, (CH2) nOA, (CH2) nOR3, CN, NO2, N (R3) 2, CH2N (H) 2-p (A) p, ( CH2) nSO2N (R3) 2, SO2N (R3) 2, (CH2) nNR3SO2A, (CH2) nSO2A, (CH2) nN (SO2A) 2, NR 3CON (R3) 2, NR3COA or NR3SO2N (R3) 2; A is a linear or branched alkyl with 1 to 12 C atoms, where one or more H atoms, preferably 1 to 7, may be substituted by Hal, OR3, CN, COOR3 or N (R3) 2 and where one or more non-adjacent CH2 groups, preferably 1 to 7, may be substituted by O, NR3 or S and / or by groups -CH>; = CH- or -C≡C-; Ar is selected from the following groups: ** Formula ** where Rb and Re are independently selected from each other from A, OA, OR3, CF3, OCF3. Het indicates one of the following groups: ** Formula ** where Rb and Re independently indicate each other A, OA, OR3, CF3, OCF3. Hal is F, CI, Br or I; R3 is H or A; p is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and the solvates, tautomers, salts and stereoisomers thereof, including mixtures thereof in all proportions.Compuestos de fórmula (I):**Fórmula** donde el grupo**Fórmula** indica uno de los siguientes grupos:**Fórmula** X indica -CH- o -N-, Y indica Het o Ar; Ra es A, Hal, CF3, OR3, OCF3, (CH2)nOH, (CH2)nOA, (CH2)nOR3, CN, NO2, N(R3)2, CH2N(H)2-p(A)p, (CH2)nSO2N(R3)2, SO2N(R3)2, (CH2)nNR3SO2A, (CH2)nSO2A, (CH2)nN(SO2A)2, NR 3CON(R3)2, NR3COA o NR3SO2N(R3)2; A es un alquilo lineal o ramificado con 1 a 12 átomos de C, donde uno o más átomos de H, preferiblemente de 1 a 7, pueden estar sustituidos por Hal, OR3, CN, COOR3 o N(R3)2 y donde uno o más grupos CH2 no adyacentes, preferiblemente de 1 a 7, pueden estar sustituidos por O, NR3 o S y/o por grupos -CH>;=CH- o -C≡C-; Ar se selecciona a partir de los siguientes grupos:**Fórmula** donde Rb y Re se seleccionan independientemente entre sí a partir de A, OA, OR3, CF3, OCF3. Het indica uno
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