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Derivatives of 9- (aryl or heteroaryl) -2- (pyrazolyl, pyrrolidinyl or cyclopentyl) aminopurine as anti-cancer agents
专利权人:
Merck Patent GmbH
发明人:
HOELZEMANN, Guenter,DORSCH, Dieter,WEGENER, Ansgar,POESCHKE, Oliver,BUSCH, Michael,SEENISAMY, Jeyaprakashnarayanan
申请号:
ES14705029
公开号:
ES2614872T3
申请日:
2014.02.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the formula I ** Formula ** in which X represents H, CH3 or NH2, R1 represents Ar or Het, R2 represents pyrazolyl, pyrrolidinyl or cyclopentyl, each of which is unsubstituted or monosubstituted by A, [C (R3) 2] pAr, [C (R3) 2] pHet1, Cyc, CO [C (R3) 2] pN (R3) 2 or CO [C (R3) 2] pHet1, R3 represents H or unbranched alkyl or branched with 1-4 C atoms, Ar represents phenyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C (R3) 2] pHet110, CONH2, CONHA and / or CONA2, Het represents pyrazolyl , pyridyl, indolyl, isoindolyl, indolinyl, quinolyl or isoquinolyl, each of which is unsubstituted or mono- or disubstituted by A and / or>; = O, Het1 represents pyrazolyl, pyridyl, pyrrolidinyl, piperidinyl, morpholinyl, tetrahydropyranyl or piperazinyl , each of which is unsubstituted or mono- or disubstituted by A and / or [C (R3) 2] pHet2, Het2 represents pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl, each of which is unsubstituted or monosubstituted by A, Cyc represents cycloalkyl with 3-7 C atoms, which is unsubstituted or monosubstituted by NH2, A represents unbranched or branched alkyl with 1-6 C atoms, wherein one or two non-adjacent CH- and / groups or CH2 can be replaced by an N-, O- and / or S- atom and where 1-7 H atoms can be replaced by F or Cl, Hal represents F, Cl, Br or I, p represents 0.1 , 2, 3 or 4, and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all proportions.Compuestos de la fórmula I**Fórmula** en la que X representa H, CH3 o NH2, R1 representa Ar o Het, R2 representa pirazolilo, pirrolidinilo o ciclopentilo, cada uno de los cuales es no sustituido o monosustituido por A, [C(R3)2]pAr, [C(R3)2]pHet1, Cyc, CO[C(R3)2]pN(R3)2 o CO[C(R3)2]pHet1, R3 representa H o alquilo no ramificado o ramificado con 1-4 átomos de C, Ar representa fenilo, que es no sustituido o mono-, di- o trisustituido por Hal, A, [C(R3)2]pHet110 , CONH2, CONHA y/o CONA2, Het repre
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