Leopold Kong,Ian A. Wilson,Natalia De Val,Andrew B. Ward,Dennis Burton,Linling He,Jiang Zhu
申请号：
US16176200
公开号：
US10647748B2
申请日:
2018.10.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
