COMPOSITIONS AND METHODS RELATED TO HIV-1 IMMUNOGENS

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专利权人:

THE SCRIPPS RESEARCH INSTITUTE

发明人:

KONG, Leopold,WILSON, Ian,DE VAL, Natalia,WARD, Andrew,BURTON, Dennis,HE, Linling,ZHU, Jiang

申请号：

SG11201809387Q

公开号：

SG11201809387QA

申请日:

2017.05.01

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

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