Analogs of benzoquinone-containing ansamycins for the treatment of cancer

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专利权人:

发明人:

申请号：

EP12168729.7

公开号：

EP2492261B1

申请日:

2004.12.23

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer (formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog.

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