Porter, James R,Pak, Roger H,Grenier, Louis,Georges Evangelinos, Asimina T,Gao, Yun,Adams, Julian,Wright, James L
申请号：
AU2004309395
公开号：
AU2004309395C1
申请日:
2004.12.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog.
