Gao, Yun,Adams, Julian,Evangelinos, Asimina T Georges,Grenier, Louis,Pak, Roger H,Porter, James R,Wright, James
申请号：
NO20062707
公开号：
NO337933B1
申请日:
2006.06.12
申请国别(地区):
NO
年份:
2016
代理人:
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer (formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog.
