Refers to compounds derived from halogenoalquil - 1,3 oxazines of formula (i) wherein R1 is alkyl, optionally substituted aryl or heteroaryl (C1 - C6), CN, cycloalkyl, among others R2 is H or alkyl Halogen Halogen R3 is (C1 - C6) R4 and R5 are H or Halogen R6 and R7 are each H or alkyl (C 1 - C6).Preferred compounds are: (S) - N - (3 - (2 - amino - 4 - (difluormetil) - 5.6 - dihydro - 4 - 1.3 - oxazin - 4-yl) - 4 - fluorfenil) - 5 - cyano - picolinamida (S) - N - (3 - (2 - amino - difluor - 5.5 - 4 - (fluormetil) - 5.6 - dihydro - 4 - 1.3 - oxazin - 4-yl) - 4 - fluorfenil) - 5 - cianopicolinamida among others. It also refers to a process of Preparation and to a Pharmaceutical composition.These compounds are inhibitors of the secretase BACE1 and BACE2 B being useful in the treatment of Alzheimers disease, Type 2 diabetes, Amyotrophic Lateral Sclerosis (ALS), arterial ThrombosisSE REFIERE A COMPUESTOS DERIVADOS DE HALOGENOALQUIL-1,3-OXAZINAS DE FORMULA (I) DONDE R1 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6), CN, CICLOALQUILO, ENTRE OTROS R2 ES H O HALOGENO R3 ES HALOGENO-ALQUILO(C1-C6) R4 Y R5 SON H O HALOGENO R6 Y R7 SON CADA UNO H O ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: (S)-N-(3-(2-AMINO-4-(DIFLUORMETIL)-5,6-DIHIDRO-4H-1,3-OXAZIN-4-IL)-4-FLUORFENIL)-5-CIANO-PICOLINAMIDA (S)-N-(3-(2-AMINO-5,5-DIFLUOR-4-(FLUORMETIL)-5,6-DIHIDRO-4H-1,3-OXAZIN-4-IL)-4-FLUORFENIL)-5-CIANOPICOLINAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SECRETASA B BACE1 Y BACE2 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DIABETES TIPO 2, ESCLEROSIS LATERAL AMIOTROFICA (ALS), TROMBOSIS ARTERIAL
