This document provides a method for the processing of formula (1) compounds,Its therapeutic use, combination with other active pharmacological agents, and pharmaceutical ingredients, claim 1: a formula compound (1),Or a pharmaceutically acceptable salt, wherein A-ring is a double ring system selected from formula group (2), in formula group (2), the wavy line represents the connection point of L1 on a rsqoe；Among them, R1 can replace the hydrogen atom in any CH bond of ring a； x1, each demonstrator is independent ch or N； X2 is n19, O, or s； X3, each demonstrator is independent N9, CH2, or s； R is 1 or 2； ring B is cyclohexane or phenyl； however, it is understood that when ring B is phenyl, Ring a is a formula (3) in which R1a is a hydrogen, phenyl, phenyl amine or 5 to 10 member heteromorphism, in which case R1a can be substituted on one or more carbon atoms and one or more R13 can be selected independently； in this case, R1a is a heteromorphism composed of one or more-nh,The hydrogen (NH) of each group can be replaced by R22； q is selected from formula group (4), in which the wavy line represents the joint point with ring B； X4 es-nr4-u-o -；Q and N are independent 0, 1, 2, 3 or 4； L1 is - nhso2,-SO2NH...-NHSO2NH- o -NHC (O) NH-R1 can replace a hydrogen atom of any CH bond in ring A and, for each presentation, is independently deuterium, hydroxyl, nitro, halogen, cyano, carboxyl, formyl, C1-7 alkyl, C3-8 carbocyclyl, alkenyl C2-7, C2-7 alkynyl, C1-7 alkoxy, C1-7 thioalkyl, C3-8 cycloalkoxy, C6-10 aryl, C6-10 aryl-C1-4 alkyl, C6-10 aryloxy, amino, N-C1 alkyl -7-amino, N, N-di- (C1-7 alkyl) -amino, C6-10-amino N-aryl, 3-10 membered heterocyclyl, N- (3-10 membered heterocyclyl) -amino, ( 3 to 10 membered heterocyclyl) -oxy, 5 to 10 membered heteroaryl, (5 to 10 membered heteroaryl) -C 1-4 alkyl, N- (5 to 10 membered heteroaryl) -amino,(5-10 membered heteroaryl) -oxyl, C1-7 alkanoyl, C1-7 alkoxycarbonyl, C1-7 alkanoyloxy, C1-7-amido alkyl, C6-10-amido aryl, (3-10 memb
