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Antibacterial condensed thiazoles
专利权人:
David John Haydon
发明人:
David John Haydon,Lloyd George Czaplewski
申请号:
US12747811
公开号:
US08299065B2
申请日:
2008.12.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compound of formula (I) have antibacterial activity: wherein: m is 0 or 1 Q is hydrogen or cyclopropyl AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl X is —C(═O)NR6—, or —C(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl Z1 is —N═ or —CH═Z2 is —N═ or —C(R1)═ R1 is hydrogen, methyl, ethyl, ethenyl, ethynyl, methoxy, mercapto, mercaptomethyl, halo, fully or partially fluorinated (C1-C2)alkyl, (C1-C2JaIkoxy or (C1-C2)alkylthio, nitro, or nitrile (—CN) R2 is a group Q1-[Alk1]q-Q2-, wherein q is 0 or 1 AIk1 is an optionally substituted, divalent, straight chain or branched C1-C6 alkylene, or C2-C6 alkenylene or C2-C6 alkynylene radical which may contain or terminate in an ether (—O—), thioether (—S—) or amino (—NR)— link Q2 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms Q1 is hydrogen, an optional substituent, or an optionally substituted carbocyclic or heterocyclic radical having 3-7 ring atoms.
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