NICHOLAS CHARLES RAY,RICHARD JAMES BULL,HARRY FINCH,MARCO VAN DEN HEUVEL,JOSE ANTONIO BRAVO
申请号：
MYPI 20070181
公开号：
MY148341A
申请日:
2007.02.07
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
COMPOUNDS OF FORMULA (I) ARE USEFUL IN THE TREATMENT OF DISEASES WHERE ENHANCED M3 RECEPTOR ACTIVATION IS IMPLICATED, SUCH AS RESPIRITORYTRACT DISEASES: WHEREIN (I) R1 IS C1-C6-ALKYL OR HYDROGEN AND R2 IS HYDROGEN OR A GROUP -R7, -Z-Y-R7 ,-Z-NR9R10 -Z-CO-NR9 R10 -Z-NR9-C(O)O-R7, OR -Z-C(O)-R7AND R3 IS A LONE PAIR, OR C1-C6-ALKYL OR (II) R1 AND R3 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED FORM A HETEROCYCLOALKYL RING, AND R 2 IS A LONE PAIR OR A GROUP –R7, -Z-Y-R7, -Z-NR9R10,-Z-CO-NR9R10, -Z-NR9-C(O)O-R7 OR -Z-C(O)-R7 OR (III) R1 AND R2 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED FORM A HETEROCYCLOALKYL RING, SAID RING BEING SUBSTITUTED BY A GROUP -Y-R7 , -Z-Y-R7 , -Z-NR9R10 -Z-CO-NR9R10 -Z-NR9-C(O)O-R7 OR -Z-C(O)-R7 AND R3 IS A LONE PAIR, OR C1-C6-ALKYL R4 AND R5 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF ARYL, ARYL-FUSED-HETEROCYCLOALKYL, HETEROARYL, C 1- C6-ALKYL, CYCLOALKYL R6 IS -OH, C1-C6-ALKYL, C,-C6-ALKOXY, HYDROXY-C1-C6-ALKYL, NITRILE, A GROUP CONR82 OR A HYDROGEN ATOM A IS AN OXYGEN OR A SULFUR ATOM X IS AN ALKYLENE, ALKENYLENE OR ALKYNYLENE GROUP R7 IS AN C1-C6-ALKYL, ARYL, ARYL-FUSED-CYCLOALKYL, ARYLFUSED-HETEROCYCLOALKYL, HETEROARYL, ARYL(C1-C8-ALKYL)-, HETEROARYL(C1-C8-ALKY)-, CYCLOALKYL OR HETEROCYCLOALKYL GROUP R8 IS C1-C6-ALKYL OR A HYDROGEN ATOM Z IS A C 1- C16ALKYLENE, C2-C16-ALKENYLENE OR C2-C16-ALKYNYLENE GROUP Y IS A BOND OR OXYGEN ATOM R9 AND R10 ARE INDEPENDENTLY A HYDROGEN ATOM, C1-C6-ALKYL, ARYL, ARYL-FUSED-HETEROCYCLOALKYL, ARYL-FUSED-CYCLOALKYL, HETEROARYL, ARYL(C1-C6-ALKYL)-, OR HETEROARYL(C1- C6-ALKYL)- GROUP OR R 9 AND R10 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A HETEROCYCLIC RING OF 4-8 ATOMS, OPTIONALLY CONTAINING A FURTHER NITROGEN OR OXYGEN ATOM.
