YOON, SANG PHIL,윤상필,KO, KI SEONG,고기성,YU, HA NA,유하나,BAIK, HYE JUNG,백혜정,YANG, WON KYU,양원규,KO, JIN YOUNG,고진영,PARK, SO HYUN,박소현,JUNG, SUNG BUM,정성범,AN, SUNG WON,안성원,KI, MIN HYO,기민효,YOON, SANG PHILKR,KO, KI SEONGKR,YU, HA NAKR,BAIK, HYE JUNGKR,YANG, WON KYUKR,KO, JIN YOUNGKR,PARK, SO HYUNKR,JUNG, SUNG BUMKR,AN, SUNG WONKR,KI, MIN HYOKR
申请号：
KR1020120157583
公开号：
KR1020140086741A
申请日:
2012.12.28
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention provides a pharmaceutical composition comprising: a) sorbitan unsaturated fatty acid ester in which two or more -OH (hydroxyl) groups exist in a polar head group； b) phospholipid； c) a liquid crystal reinforcing agent without an ionized group in which the hydrophobic portion thereof has a triacyl group with 15-40 carbon atoms or has a carbon ring structure； and d) a gonadotropin-releasing hormone (GnRH) derivative as a pharmacological active substance. The pharmaceutical composition is in lipid-liquid phase in the absence of aqueous fluid, and forms a liquid crystal in the aqueous fluid. The pharmaceutical composition of the present invention exhibits an effect in reinforcing the sustained release properties of the GnRH derivative, which is a pharmacological active substance.본 발명은 a) 극성헤드기에 -OH(hydroxyl)기가 2개 이상 존재하는 솔비탄 불포화지방산 에스터(sorbitan unsaturated fatty acid ester)； b) 포스포리피드(phospholipid)； c) 이온화기를 가지지 않고, 소수성 부분은 탄소수가 15개 내지 40개 의 트리아실기를 가지거나 탄소링 구조를 가지는 액상결정 강화제(liquid crystal hardener)； 및 d) 약리학적 활성물질로서 GnRH(gonadotropin-releasing hormone) 유도체를 포함하고, 수성유체가 없는 상태에서 지질 액상이며, 수성유체 상에서 액상결정(liquid crystal)을 형성하는 약제학적 조성물을 제공한다.본 발명에 따른 약제학적 조성물은 약리학적 활성물질인 GnRH 유도체의 서방성을 증대시키는 작용효과를 나타낸다.
