Yoon, Sang Phil,Ko, Ki Seong,Yu, Ha Na,Baik, Hye Jung,Yang, Won Kyu,Ko, Jin Young,Park, So Hyun,Jung, Sung Bum,An, Sung Won,Ki, Min Hyo
申请号：
AU2013371101
公开号：
AU2013371101B2
申请日:
2013.12.27
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups； b) at least one phospholipid； c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety； and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.
