YOON, Sang Phil,KO, Ki Seong,YU, Ha Na,BAIK, Hye Jung,YANG, Won Kyu,KO, Jin Young,PARK, So Hyun,JUNG, Sung Bum,AN, Sung Won,KI, Min Hyo
申请号：
PH12015500936
公开号：
PH12015500936B1
申请日:
2015.04.27
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups； b) at least one phospholipid； c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety； and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.
