KO, JIN YOUNG,KIM, JI YEON,PARK, SO HYUN,AN, SUNG WON,KI, MIN HYO
申请号：
EP12826818
公开号：
EP2750667A4
申请日:
2012.08.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups b) a phospholipid and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also, a pharmaceutical composition further comprising a pharmacologically active ingredient plus the pre-concentrate is provided.
